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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Polyamine Metabolism as a Metabolic Vulnerability in Prostate Cancer Treated with Supraphysiological Androgens

Mohammadreza Alizadeh-Ghodsi1,2, Andrew S Goldstein3,4,5,6

  • 1Department of Urologic Sciences, The University of British Columbia, Vancouver, Canada.

Cancer Research
|March 2, 2026
PubMed
Summary

Cyclic supraphysiologic androgen (SPA) therapy for prostate cancer alters cell metabolism by increasing polyamine synthesis and depleting S-adenosylmethionine (SAM). Inhibiting polyamine production with DFMO enhances SPA

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