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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Minocycline is a widely used antibiotic for various infections.
  • Minocycline-induced hyperpigmentation is a known but often underrecognized adverse effect.

Purpose of the Study:

  • To present two cases of minocycline-induced hyperpigmentation.
  • To highlight the diverse clinical presentations of this side effect.
  • To emphasize the importance of early recognition and judicious minocycline use.

Main Methods:

  • Case report presentation.
  • Clinical observation of patient presentations.
  • Review of minocycline's adverse effect profile.

Main Results:

  • Two patients exhibited significant minocycline-induced hyperpigmentation.
  • Hyperpigmentation occurred at diverse body sites.
  • The condition can lead to irreversible skin discoloration if not managed promptly.

Conclusions:

  • Minocycline can cause significant and diverse skin hyperpigmentation.
  • Prompt recognition of minocycline's adverse effects is essential.
  • Judicious antibiotic prescribing can mitigate the risk of irreversible hyperpigmentation.