A combined automatic organ at risk contouring and synthetic Computed Tomography solution for pelvic Magnetic...

Magnetic Resonance (MR)-only radiotherapy improves treatment accuracy and efficiency but requires a synthetic Computed Tomography (sCT) for dose calculations. Automatic MR-based Organs At Risk (OARs) contouring could further improve consistency and efficiency. A combined automatic MR OAR contouring and sCT solution has been developed, with each component separately validated. This study aimed to evaluate this combined MR-only workflow against a manual MR-CT workflow for pelvic cancers.

Radiotherapy MR and CT scans were acquired for 20 patients (10 prostate, 4 rectum, 6 anus cancer). The MR-only workflow used sCTs and automatic contours for the bladder, bowel bag, femoral heads, rectum, penile bulb, prostate, seminal vesicles and urethra along with manual target contours to optimise a MR-only plan. Doses were compared to the current clinical standard of deformably registered CT and manual MR OAR contours (MR-CT).

Mean dose differences were $\le 1\mathrm{Gy}$ ; 1 percentage point relative volume for all OARs except the bowel bag. Mean absolute dose differences were also $\le 1\mathrm{Gy}$ for all OARs except bowel bag in ano-rectal patients and except bowel bag, bladder V $50\mathrm{Gy}$ , V $40\mathrm{Gy}$ , V $30\mathrm{Gy}$ and rectum V $30\mathrm{Gy}$ in prostate patients.

The automatic MR OAR contouring and sCT workflow had similar dose differences to manual inter-observer variability for all OARs except the lower dose bladder and rectum volumes (prostate patients only) and bowel bag (prostate and ano-rectal patients). This combined OAR contouring and MR-only workflow could enable more efficient and consistent pelvic radiotherapy treatment.