Probiotic-based therapeutics for a One Health future: redefining antibiotic dependency to combat antimicrobial...

Area of Science:

• Microbiology
• Ecology
• Public Health

Background:

• Antimicrobial resistance (AMR) is a significant global One Health challenge.
• Extensive antibiotic use has disrupted ecological balance and expanded the global resistome.
• Current AMR control strategies are often reactive and dependent on antibiotics.

Purpose of the Study:

• To propose a novel, ecological restoration-based strategy for mitigating AMR.
• To integrate probiotic therapeutics, microbiome literacy, and advanced surveillance into AMR management.
• To shift AMR control towards a resilient, coexistence-based approach.

Main Methods:

• Utilizing probiotic therapeutics for microbial stability and reducing resistance selective pressures.
• Enhancing public awareness and literacy regarding the microbiome and antimicrobial stewardship.
• Implementing the One Health Microbiome Intelligence Framework (OH-MIF) for integrated data analysis.

Main Results:

• Probiotics offer biologically compatible solutions by promoting niche occupation, immune support, and biodegradation.
• Increased microbiome literacy can influence behavior, promoting stewardship and reducing antimicrobial misuse.
• The OH-MIF framework links diverse data sources (genomic, clinical, agricultural, environmental) using AI.

Conclusions:

• A three-part strategy combining probiotics, education, and data intelligence offers a sustainable AMR mitigation approach.
• Ecological interventions and microbiome balance are key to resilient AMR control.
• This approach aligns AMR management with broader planetary health objectives.