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Related Experiment Video

Updated: Mar 3, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Towards noninvasive white blood cell count.

Arutyun Bagramyan^1,2, Juwell W Wu¹, Kamdin Mirsanaye¹

¹Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Biomedical Optics Express

|March 2, 2026

Summary

This summary is machine-generated.

A new noninvasive method uses a miniaturized microscope to image oral mucosa for white blood cell counts (WBCC). This technology offers a safer, accessible alternative to traditional blood draws for immune system monitoring.

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Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

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Published on: March 22, 2022

Area of Science:

Biomedical Engineering
Optical Imaging
Immunology

Background:

Current immune system monitoring relies on invasive blood draws (white blood cell count - WBCC).
Blood draws pose risks like infection and anemia, and require specialized resources.
Noninvasive methods for immune status assessment are lacking.

Purpose of the Study:

To develop and validate a noninvasive, label-free method for white blood cell count (WBCC).
To enable real-time immune status assessment without repetitive blood sampling.

Main Methods:

Utilized a miniaturized oblique back-illumination microscope (mOBM) to image human oral mucosa.
Developed an analytical pipeline for label-free cell detection and quantification.
Validated the system in a pilot study with 34 healthy subjects.

Main Results:

Successfully detected and quantified circulating leukocytes via oral mucosa imaging.
Image-based WBCCs correlated with standard laboratory measurements.
Demonstrated the feasibility of noninvasive WBCC.

Conclusions:

The mOBM system provides a noninvasive approach for white blood cell counts (WBCC).
This technology can facilitate real-time immune status monitoring in various clinical settings.
Offers a safer and more accessible alternative to traditional blood sampling.