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Association of Posttransplant Kidney Function With Patient Reported Outcomes: A Single Center's Experience Over
Peter Thorne1,2, Laura A Binari2, Scott A Rega3
1Division of Nephrology and Hypertension, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
Clinical Transplantation
|March 2, 2026
Summary
Kidney transplant recipients with lower estimated glomerular filtration rate (eGFR) experience poorer physical health-related quality of life (HRQOL) and more depression and anxiety symptoms. Maintaining optimal graft function is crucial for improving patient well-being.
Area of Science:
- Nephrology
- Transplantation Medicine
- Psychosomatic Medicine
Background:
- Chronic kidney disease (CKD) impairs quality of life in non-transplant patients.
- The link between kidney transplant graft function (eGFR) and patient-reported outcomes (PROs) is not well understood.
- This study investigates the association between eGFR and PROs in kidney transplant recipients.
Purpose of the Study:
- To evaluate the relationship between estimated glomerular filtration rate (eGFR) and patient-reported outcomes (PROs) in kidney transplant recipients.
- To identify clinical strategies for optimizing physical and psychological well-being in this population.
- To understand how graft function impacts quality of life and mental health post-transplant.
Main Methods:
- Longitudinal data from 2116 adult kidney transplant recipients over 19 years.
- Logistic regression and multivariable mixed-effects models analyzed associations between eGFR strata and PROs.
- PRO battery assessed physical/mental health-related quality of life (HRQOL) and symptoms of depression/anxiety.
Main Results:
- Lower eGFR was significantly associated with lower physical HRQOL (p < 0.001).
- CKD stage 4 or 5 increased odds of depression (OR: 1.50) and anxiety (OR: 1.48) compared to eGFR ≥ 60.
- Higher eGFR correlated with better physical/mental HRQOL and reduced depression/anxiety symptoms longitudinally.
Conclusions:
- Impaired kidney graft function is linked to reduced physical HRQOL and increased psychological distress in transplant recipients.
- Close monitoring and early interventions are vital as graft function declines.
- Optimizing graft function is key to enhancing overall well-being in kidney transplant patients.
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