Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

855
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
855
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.4K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.4K
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.3K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.3K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

808
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
808
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

976
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
976
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

511
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
511

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thyroid Function Parameters, Thyroid Status, and Vitamin B12 Deficiency in Hospitalized Adults: A Retrospective Cross-Sectional Study in Eastern India.

Cureus·2026
Same author

Coexistence of Anaemia and Common Morbidities Among Children in India Below the Age of Five Years: Evidence From the National Family Health Survey-5 (2019-21).

Cureus·2026
Same author

Pathogen-mediated priming induces intergenerational immunity against spot blotch in wheat.

World journal of microbiology & biotechnology·2026
Same author

Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Machine learning framework for cost effective deep mutational scanning through targeted substitution profiling.

BMC bioinformatics·2026
Same author

Gold nanoparticle-based electrophoresis-free colorimetric detection method for allele-specific PCR-SNP genotyping.

Analytical biochemistry·2026
Same journal

Specialized or General-Purpose-The Wrong Question for Mental Health AI Safety.

JAMA·2026
Same journal

Pricing for Oncology Biosimilars.

JAMA·2026
Same journal

Familial Hypercholesterolemia.

JAMA·2026
Same journal

Reporting Error.

JAMA·2026
Same journal

Replacement Text for Funding/Support Section.

JAMA·2026
Same journal

Pricing for Oncology Biosimilars-Reply.

JAMA·2026
See all related articles

Related Experiment Video

Updated: Mar 3, 2026

Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment
03:25

Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment

Published on: December 27, 2024

1.7K

Chronic, Noninfectious Diarrhea: A Review.

Prashant Singh1, Allen Lee1, Neil M Sheth1

  • 1Division of Gastroenterology & Hepatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor.

JAMA
|March 2, 2026
PubMed
Summary
This summary is machine-generated.

Chronic diarrhea affects millions, often stemming from noninfectious causes like IBS-D. Diagnosis involves ruling out celiac disease, IBD, and microscopic colitis, with treatments including lifestyle changes and medications.

More Related Videos

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.7K
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

3.3K

Related Experiment Videos

Last Updated: Mar 3, 2026

Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment
03:25

Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment

Published on: December 27, 2024

1.7K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.7K
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

3.3K

Area of Science:

  • Gastroenterology
  • Internal Medicine

Background:

  • Chronic diarrhea, defined as lasting over 4 weeks, affects 6-7% of US adults, with over 90% having noninfectious causes.
  • Common noninfectious etiologies include irritable bowel syndrome with diarrhea (IBS-D) and functional diarrhea, distinguished by abdominal pain and stool characteristics.

Purpose of the Study:

  • To outline the common causes, diagnostic approaches, and therapeutic strategies for chronic noninfectious diarrhea.
  • To emphasize the importance of differentiating between various causes for targeted treatment.

Main Methods:

  • Review of common causes: IBS-D, functional diarrhea, celiac disease, small intestinal bacterial overgrowth, bile acid diarrhea, and microscopic colitis.
  • Diagnostic considerations include serological testing for celiac disease, fecal calprotectin for inflammatory bowel disease, and colonoscopy with biopsies for microscopic colitis.
  • Evaluation for colorectal cancer is recommended in specific patient groups.

Main Results:

  • IBS-D and functional diarrhea are the most frequent diagnoses when specific organic causes are not identified.
  • Microscopic colitis is found in 13% of chronic diarrhea cases upon colon biopsy.
  • Therapeutic interventions, including lifestyle modifications and medications, can improve symptoms in 50-80% of patients.

Conclusions:

  • Key differential diagnoses for chronic diarrhea include IBS-D, functional diarrhea, celiac disease, inflammatory bowel disease, and microscopic colitis.
  • A systematic diagnostic approach is crucial for effective management.
  • Empiric treatment with lifestyle adjustments, dietary changes, or medications can significantly alleviate symptoms.