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Published on: July 7, 2013
Nanoparticle IL-33 Covalent Pericardial Patch Inhibits Pseudoaneurysm Formation after Aortic Patch Angioplasty
Liwei Zhang1, Lingyi Che2, Zhiwen Zhang1
1Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
ACS Applied Bio Materials
|March 2, 2026
Summary
Interleukin-33 (IL-33) reduces pseudoaneurysm formation by enhancing the transforming growth factor-beta (TGF-β) pathway. An IL-33-coated pericardial patch shows potential for preventing pseudoaneurysms after vascular surgery.
Area of Science:
- Vascular Biology
- Regenerative Medicine
- Nanotechnology
Background:
- Pseudoaneurysm formation following vascular injury lacks a clear mechanism.
- Interventional surgery and vascular trauma are common causes of pseudoaneurysms.
Purpose of the Study:
- To elucidate the role of Interleukin-33 (IL-33) in pseudoaneurysm development.
- To engineer a pericardial patch with IL-33-loaded PLGA nanoparticles to prevent pseudoaneurysms.
Main Methods:
- Rat models of pseudoaneurysm were treated with IL-33 or TGF-β coated patches.
- Histological and immunofluorescence analyses assessed elastic fiber integrity, cell proliferation, and macrophage infiltration.
- Inhibition of the TGF-β pathway was evaluated using SB431542.
Main Results:
- Both NP-TGF-β and NP-IL-33 coated patches significantly inhibited pseudoaneurysm formation (p=0.0041, p=0.0246).
- IL-33 administration increased TGF-β expression (p=0.0009) and decreased M1 macrophage infiltration (p=0.0009).
- IL-33 mitigated pseudoaneurysm formation induced by TGF-β inhibition.
Conclusions:
- IL-33 promotes pseudoaneurysm resolution by upregulating the TGF-β pathway.
- Pericardial patches coated with IL-33 PLGA nanoparticles offer a promising therapeutic strategy for post-angioplasty pseudoaneurysm prevention.
