Rauhut-Currier Reaction-Inspired Intramolecular Cyclization Approach Using DBU to Access Biaryl-Fused
Prashant Kumar Sinha1,2, Ravula Shivakumar1,2, Jagadeesh Babu Nanubolu3
1Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India.
Abstract:
In this paper, an efficient intramolecular DBU-catalyzed Rauhut-Currier reaction has been described to access functionalized biaryl-fused cycloheptatriene derivatives. The method is operationally simple, displays broad substrate compatibility, and consistently delivers the products in good to excellent yields with high diastereoselectivities. The scalability of the process to gram-scale syntheses, combined with facile postsynthetic functionalizations, underscores the flexibility and usefulness of this strategy.
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