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Orbital Abscess in an Infant With STAT3 Hyper-IgE Syndrome.

Lucas McGuire1, Neda Esmaili2

  • 1From the School of Medicine, Medical College of Wisconsin.

Ophthalmic Plastic and Reconstructive Surgery
|March 2, 2026
PubMed
Summary

A rare infant orbital cellulitis case revealed Hyper-IgE syndrome due to a novel STAT3 mutation. Prompt treatment and immune evaluation are crucial for such complex pediatric cases.

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Area of Science:

  • Pediatrics
  • Immunology
  • Ophthalmology

Background:

  • Orbital cellulitis (OC) is uncommon in infants.
  • Early diagnosis and intervention are critical for managing OC.

Purpose of the Study:

  • To report a unique case of infantile orbital cellulitis.
  • To highlight the association with Hyper-IgE syndrome and a novel STAT3 mutation.

Main Methods:

  • Clinical case presentation of a 34-day-old female with periorbital swelling and proptosis.
  • Diagnostic imaging (CT/MRI), surgical drainage, antibiotic therapy, and laboratory investigations including genetic testing.
  • Identification of methicillin-sensitive Staphylococcus aureus and a novel STAT3 mutation.

Main Results:

  • The patient presented with severe orbital cellulitis and ethmoid sinusitis.
  • Treatment included urgent surgical drainage and broad-spectrum antibiotics.
  • Postoperative findings of leukocytosis, eosinophilia, recurrent skin abscesses, and genetic identification of a novel STAT3 mutation confirmed Hyper-IgE syndrome.

Conclusions:

  • Infantile orbital cellulitis requires prompt surgical and medical management.
  • Atypical findings in pediatric orbital cellulitis warrant investigation for underlying immune dysregulation.
  • This is the first reported case of infantile orbital cellulitis associated with Hyper-IgE syndrome and a novel STAT3 variant.