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Irisin and the kidney: Key points to know?
Danilo Candido de Almeida1, Juan Sebastian Henao Agudelo2
1Federal University of São Paulo, School of Medicine, Division of Nephrology , São Paulo, Brazil.
Nefrologia
|March 2, 2026
Summary
Irisin, a hormone released by exercise, impacts kidney health and disease. This review explores irisin
Area of Science:
- Endocrinology and Metabolism
- Nephrology
- Exercise Physiology
Background:
- Irisin, a myokine from FNDC5, mediates exercise benefits on metabolic homeostasis.
- Growing evidence links irisin levels to kidney pathophysiology, including chronic kidney disease.
- Irisin's role in diabetic nephropathy and acute kidney injury is under investigation.
Purpose of the Study:
- To review the mechanisms of irisin's involvement in renal pathophysiology.
- To elucidate irisin's complex interaction with kidney disease.
- To highlight irisin's potential as a biomarker and therapeutic target in nephrology.
Main Methods:
- Mini-review consolidating current research findings.
- Analysis of mechanistic underpinnings of irisin in renal pathophysiology.
- Exploration of irisin's interplay with various kidney diseases.
Main Results:
- Irisin is implicated in regulating inflammatory, oxidative, and fibrotic pathways relevant to kidney health.
- Irisin levels correlate with renal pathophysiology in conditions like chronic kidney disease.
- Emerging data suggest irisin modulates renal function in diabetic nephropathy and acute kidney injury.
Conclusions:
- Irisin plays a significant role in modulating kidney function and disease progression.
- Understanding irisin's mechanisms in nephrology is crucial for future therapeutic strategies.
- Irisin shows promise as a diagnostic biomarker and a novel therapeutic target for kidney diseases.
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