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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
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Monocyte Distribution Width Differentiates Bacterial Enterocolitis from Acute Severe Ulcerative Colitis in the
Christopher F D Li Wai Suen1,2,3, Shipraa Kaul2, Ethan X Z Tan2
1Department of Medicine (Austin Health), The University of Melbourne, Melbourne, VIC, Australia.
Digestive Diseases and Sciences
|March 2, 2026
Summary
Monocyte distribution width (MDW) can help differentiate bacterial enterocolitis from acute severe ulcerative colitis (ASUC). Higher MDW levels in ASUC patients may predict infliximab response and identify remission.
Area of Science:
- Gastroenterology
- Hematology
- Clinical Diagnostics
Background:
- Distinguishing bacterial enterocolitis from acute severe ulcerative colitis (ASUC) presents a diagnostic challenge.
- Monocytes, involved in ASUC pathogenesis, exhibit size variations measurable as monocyte distribution width (MDW).
Purpose of the Study:
- To evaluate MDW's ability to differentiate bacterial enterocolitis from ASUC.
- To assess MDW's predictive value for therapeutic response in ASUC patients.
Main Methods:
- A retrospective cohort study included 176 patients across three groups: ASUC, bacterial enterocolitis, and controls.
- MDW, routine biomarkers (CRP, fecal calprotectin), and clinical outcomes were analyzed.
- The study assessed MDW's performance in distinguishing between ASUC and bacterial enterocolitis and predicting ASUC treatment response and remission.
Main Results:
- Bacterial enterocolitis patients exhibited significantly higher MDW than ASUC and control groups (P < 0.001).
- MDW effectively discriminated between bacterial enterocolitis and ASUC (AUC: 0.78).
- In ASUC, MDW predicted infliximab response (AUC: 0.80) and identified biochemical remission at 3 months (AUC: 0.80).
Conclusions:
- MDW emerges as a potential novel biomarker for differentiating ASUC from bacterial enterocolitis.
- MDW may predict infliximab response and identify biochemical remission in ASUC patients.
- Further validation studies are necessary to confirm MDW's clinical utility.
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