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Published on: October 31, 2013
APC-Mutated MUC4-Positive Fibroblastoma With Cytoplasmic β-Catenin: A Novel Variant Expanding Its Immunophenotypic
Amanda Onalaja-Underwood1, Rana Naous1
1Pathology, The Ohio State University Wexner Medical Center, Columbus, USA.
Cureus
|March 3, 2026
Summary
MUC4-positive fibroblastoma, a rare tumor, can present atypically. This case shows MUC4 expression without typical β‑catenin staining, expanding diagnostic possibilities for this fibroblastic neoplasm.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- MUC4-positive fibroblastoma is a recently identified fibroblastic neoplasm.
- It typically exhibits diffuse MUC4 expression, nuclear β‑catenin positivity, and APC gene alterations.
- Understanding its immunophenotypic spectrum is crucial for accurate diagnosis.

