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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

328
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
328
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

288
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
288
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

766
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
766
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

292
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
292
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

303
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
303
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

277
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
277

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Updated: Mar 4, 2026

Multi-Modal Home Sleep Monitoring in Older Adults
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Developing mHealth IT for Older Adult Medication Safety: Remote Participatory Co-Design Using the RAPID Method.

Jordan R Hill1, Aaron Ganci2, Noll L Campbell3,4

  • 1Department of Health & Wellness Design, School of Public Health - Bloomington, Indiana University, 1025 E 7th St, Bloomington, IN, 47405, United States, 1 812-856-5032.

JMIR Human Factors
|March 3, 2026
PubMed
Summary
This summary is machine-generated.

Remote co-design enhances health intervention development by increasing reach and flexibility. Our RAPID method offers a structured approach, balancing convenience with potential time increases for remote participatory design.

Keywords:
co-designdigital healthhealth interventionolder adultsparticipatory designpharmacyremote

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Area of Science:

  • Health Informatics
  • Human-Computer Interaction
  • Participatory Design

Background:

  • Participatory co-design is increasingly used in healthcare, shifting from in-person to remote methods.
  • Remote co-design offers benefits like expanded reach, diverse recruitment, reduced power dynamics, and enhanced engagement.
  • Further refinement and reporting of remote co-design methods are necessary.

Purpose of the Study:

  • To present the Remote and Accessible Participatory Intervention Design (RAPID) method.
  • To discuss challenges and choices in adapting co-design for remote use in healthcare.

Main Methods:

  • Adapted a 5-step in-person co-design method for remote application.
  • Recruited two groups (older adult pharmacy patients and pharmacy staff) for co-design.
  • Focused on designing a digital kiosk for safe over-the-counter medication purchases.

Main Results:

  • Adaptations spanned facilitation, collaboration, communication, sensemaking, accessibility, tools, and compliance.
  • Remote co-design sessions were shorter, potentially increasing overall duration but allowing flexible scheduling.
  • The process facilitated remote collaboration for intervention design.

Conclusions:

  • The RAPID method provides a framework for remote co-design implementation.
  • Remote co-design presents drawbacks but offers significant advantages in convenience and flexibility.
  • The experiences highlight the need for careful planning in remote participatory design.