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Updated: Jul 2, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Role of biomechanical factors in plaque rupture and erosion: insight from intravascular imaging based computational
Liang Wang1, Yanwen Zhu1, Chen Zhao2
1School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Abstract:
Coronary biomechanics including structural wall stress and strain on the vessel wall and flow wall shear stress on the endothelial surface play a vital role in plaque progression, rupture and erosion. This review summarizes recent advances in coronary intravascular imaging, image-based biomechanical modeling, and their applications in investigating possible biomechanical mechanisms of plaque rupture and erosion, and developing interventional therapies targeting unfavorable mechanical conditions for personalized treatment and precision medicine.
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