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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri)
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Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish.

Emma K Costa1,2,3, Jingxun Chen3,4, Ian H Guldner1,3

  • 1Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Nature Aging
|March 3, 2026
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Summary

This study maps aging across 13 tissues in the African turquoise killifish, revealing conserved aging patterns and sex-specific differences. It identifies biomarkers and develops "transcriptomic clocks" to predict age and evaluate lifespan interventions.

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Area of Science:

  • Gerontology
  • Comparative genomics
  • Vertebrate aging models

Background:

  • Aging is a complex process involving progressive tissue dysfunction, frailty, and mortality.
  • Understanding tissue-specific and systemic aging mechanisms is vital for developing interventions.
  • The African turquoise killifish offers a unique, short-lived vertebrate model for aging research.

Purpose of the Study:

  • To create a comprehensive aging atlas across 13 tissues in the African turquoise killifish.
  • To characterize sex- and age-related changes in gene expression and biological pathways.
  • To develop and validate tissue-specific transcriptomic clocks for age prediction and intervention evaluation.

Main Methods:

  • RNA sequencing of 13 tissues from male and female killifish at six different ages.
  • Analysis of gene expression, sex-age interactions, and conserved biological pathways.
  • Development and validation of tissue-specific transcriptomic clocks using independent datasets.

Main Results:

  • Identification of varying sex-age interaction strengths across tissues.
  • Discovery of conserved age-altered genes and pathways in mice and humans.
  • Development of tissue-specific transcriptomic clocks and age-predictive biomarkers.
  • Observation of a female-biased myeloid shift in the killifish hematopoietic organ with age.

Conclusions:

  • The African turquoise killifish serves as a powerful model for studying aging dynamics across tissues.
  • Transcriptomic clocks provide a valuable tool for age prediction and assessing lifespan interventions.
  • The study highlights conserved aging mechanisms and sex-specific differences relevant to human aging.