[Present-day methods of therapeutic angiogenesis (literature review)]

Therapeutic angiogenesis is a trend of treatment based on stimulating the growth of new blood vessels to fill the perfusion deficiency and thereby restore the function of a damaged organ. It is especially important in case of inefficiency or impossibility of surgical methods to re-establish perfusion of ischemic tissues. This method can also be effective at the initial stages of ischemic processes, including for the prevention of disease progression and the development of complications.Most technologies for stimulating angiogenesis are based on the creation of a high concentration of angiogenic growth factors. Physical and chemical methods can be used to stimulate the production of endogenous proangiogenic molecules. However, the clinical status of patients often implies the presence of defects in the endogenous mechanisms of regulation of angiogenic processes, therefore, the main trend in research is the development of methods for adequate repair of the mechanisms of regulation of angiogenesis. This review presents data on modern technologies of therapeutic angiogenesis, separately considering the state of the art of methods based on therapy with recombinant growth factors, encoding genes, as well as cells and their derivatives, also discussing peculiarities, advantages, and limitations of each of the methods.