Related Experiment Video
Updated: Jul 21, 2026
04:33
CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics
Published on: December 8, 2023
PyTTA-HOF/MXene integration with a CRISPR/Cas12 strategy for advanced homogeneous photoelectrochemical sensing
Hui-Li Yu1, Jia-Le Wang1, Qin-Xia Du2
1School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P.R. China.
Chemical Communications (Cambridge, England)
|March 4, 2026
Abstract:
An advanced homogeneous photoelectrochemical (PEC) sensing strategy is designed based on the integration of the excellent PEC performance of PyTTA-HOF/MXene with CRISPR/Cas12a-mediated signal transduction and amplification, which can effectively avoid cumbersome, multi-step electrode modification and demonstrates satisfactory detection performance for the clinically relevant HPV-16 gene.
Related Concept Videos
01:59CRISPR
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
02:31Homologous Recombination
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...