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Sleep-Disordered Breathing Shortly After Stroke Is Not Associated With Poststroke Fatigue at 3 Months.

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Sleep-disordered breathing shortly after stroke does not predict post-stroke fatigue at three months. These findings suggest that treating sleep-disordered breathing may not alleviate fatigue in stroke survivors.

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Area of Science:

  • Neurology
  • Sleep Medicine
  • Cardiovascular Research

Background:

  • Post-stroke fatigue (PSF) is a prevalent and often debilitating condition following a stroke.
  • The underlying causes of PSF remain poorly understood, necessitating further investigation.
  • Sleep-disordered breathing (SDB) is common after stroke and is known to cause fatigue.

Purpose of the Study:

  • To evaluate the association between SDB measured shortly after stroke and PSF at 3-months.
  • To determine if SDB could be a potential intervention target for managing PSF.

Main Methods:

  • A multi-center cohort study involving ischemic stroke (IS) patients.
  • Overnight SDB screening using a home sleep apnea test (ApneaLink Plus™) to measure the respiratory event index (REI).
  • PSF assessed at 3-months post-stroke using the SF-36 vitality scale; multivariable linear regression was used for analysis.

Main Results:

  • 355 IS participants completed baseline SDB screening and 3-month PSF assessments.
  • SDB was common, with a median baseline REI of 17. No significant association was found between baseline REI and 3-month PSF in adjusted models.
  • Age and Mexican American ethnicity were linked to lower fatigue, while female sex and depression treatment were linked to higher fatigue.

Conclusions:

  • Sleep-disordered breathing in the immediate post-stroke period does not predict post-stroke fatigue at 3 months.
  • While identifying and treating SDB post-stroke may be important for other reasons, it is unlikely to impact PSF.