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Invasive Aspergillus Tracheobronchitis Presenting as Subglottic Stenosis: A Case Report.
Takaya Sato1, Kentaro Minegishi1, Masatomo Miyata1
1Department of General Thoracic Surgery Jichi Medical University Saitama Medical Center Saitama Japan.
Respirology Case Reports
|March 4, 2026
Summary
Invasive Aspergillus tracheobronchitis (IATB) is a rare fungal infection. Early diagnosis and voriconazole treatment in an immunocompromised patient led to successful recovery, highlighting the importance of prompt intervention.
Area of Science:
- Medical Mycology
- Pulmonology
- Infectious Diseases
Background:
- Invasive Aspergillus tracheobronchitis (IATB) is a rare, life-threatening fungal infection.
- High mortality necessitates rapid diagnosis and treatment.
Purpose of the Study:
- To report a case of IATB in an immunocompromised patient.
- To emphasize the importance of early diagnosis and intervention.
Main Methods:
- Case report of a 71-year-old woman with DLBCL.
- Diagnosis confirmed by histopathological and microbiological examination of bronchoscopic biopsies.
- Treatment with voriconazole and emergency tracheostomy.
Main Results:
- Successful treatment of IATB with voriconazole.
- Resolution of subglottic airway stenosis and successful tracheostomy tube removal.
- Favorable outcome achieved through timely antifungal therapy and airway management.
Conclusions:
- Early diagnosis and prompt antifungal therapy are critical for managing IATB.
- Airway interventions like tracheostomy can be lifesaving in severe cases.
- This case highlights successful management of IATB in an immunocompromised patient.
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