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Related Experiment Video

Updated: May 11, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
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The Intimate Relationship between Adipose Tissue, Fertility, and Bone.

Olympia Michalopoulou1, Ifigenia Kostoglou-Athanassiou2, Georgios Troupis3

  • 1Endocrine Unit and Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Journal of Frailty, Sarcopenia and Falls
|March 4, 2026
PubMed
Summary
This summary is machine-generated.

Adipose tissue is a key endocrine organ influencing metabolism, reproduction, and bone health. Its signals interact with reproductive and skeletal systems, impacting fertility and bone integrity.

Keywords:
AdipokinesAdipose tissueBone marrow adipose tissueFertilityVitamin D

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Area of Science:

  • Endocrinology
  • Metabolic Physiology
  • Skeletal Biology

Background:

  • Adipose tissue functions as a dynamic endocrine organ, secreting adipokines that regulate reproductive and skeletal systems.
  • Complex interplay exists between adipose tissue, bone, and the reproductive system, linking energy balance, fertility, and bone homeostasis.
  • Adipokines and bone-derived proteins, alongside Vitamin D, form intricate networks influencing steroidogenesis and metabolic function.

Purpose of the Study:

  • To review mechanistic and clinical evidence on adipose tissue signaling to gonadal and skeletal tissues.
  • To explore depot-specific effects and bidirectional feedback within the adipose-bone-reproductive axis.
  • To highlight implications for infertility, osteoporosis, and metabolic bone disease, identifying therapeutic targets.

Main Methods:

  • Comprehensive literature review of mechanistic and clinical studies.
  • Analysis of signaling pathways involving adipokines (leptin, adiponectin, resistin, visfatin), osteocalcin, and Vitamin D.
  • Examination of endocrine, paracrine, and autocrine communication networks.

Main Results:

  • Adipose tissue signals significantly modulate reproductive function and bone remodeling.
  • Bidirectional communication between adipose tissue and bone is crucial for metabolic and skeletal health.
  • Disruptions in this network are linked to infertility and metabolic bone disorders.

Conclusions:

  • Adipose tissue plays a central role in integrating metabolic, reproductive, and skeletal physiology.
  • Understanding these complex interactions offers potential for novel therapeutic strategies.
  • Further research is needed to address knowledge gaps in treating related disorders.