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Microalgal therapeutic peptides: From biomass to bone tissue engineering
Diana Pacheco1,2, Tatiana M F Patrício2,3, Abílio J F N Sobral1
1Coimbra Chemistry Centre-Institute of Molecular Sciences (CQC-IMS), Department of Chemistry, University of Coimbra, Coimbra, 3004-535, Portugal.
Materials Today. Bio
|March 4, 2026
Summary
Microalgae-derived peptides show promise for bone tissue engineering due to their biocompatibility and osteogenic activity. This review explores their extraction, properties, and application in developing advanced biomaterials for bone regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Marine Biotechnology
Background:
- Bone tissue engineering faces challenges with synthetic biomaterials lacking cellular compatibility and biological activity.
- Natural and biomimetic alternatives are sought for improved integration with native bone tissue.
- Microalgae offer a sustainable source of biologically active compounds, including peptides with therapeutic potential.
Purpose of the Study:
- To provide a comprehensive review of microalgae-derived peptides for bone regeneration.
- To cover the manufacturing process, biological properties, and therapeutic applications.
- To examine clinical translation challenges and the potential of advanced delivery systems.
Main Methods:
- Literature review focusing on microalgae protein extraction, peptide purification, and characterization.
- Analysis of biological activities, particularly osteogenic potential.
- Evaluation of therapeutic applications and clinical study status.
Main Results:
- Microalgae-derived peptides exhibit high cellular compatibility and osteogenic activity.
- Their tunable properties make them suitable for developing advanced biomaterials.
- Integration with advanced delivery systems can enable patient-specific implants.
Conclusions:
- Microalgae are a significant, sustainable resource for therapeutic peptides in bone regenerative medicine.
- These peptides hold potential for the next generation of biomaterials.
- Further research into clinical translation and delivery systems is warranted.
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