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Published on: June 11, 2012
Real-World Experience With Control-IQ Technology in Saudi Children With Insulin-Dependent Diabetes: A Single-Center
Afaf Alsagheir1,2, Bassam Bin-Abbas1,2, Razan Alsagheir1
1Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia, kfshrc.edu.sa.
Objectives:
The Tandem t:slim X2 insulin pump with the Control-IQ technology (Control-IQ) is an automated insulin delivery (AID) system for glycemic control but has limited data in Saudi pediatric and young adult populations. We aim to evaluate the efficacy and safety of Control-IQ therapy in children with insulin-dependent diabetes and previously treated with multiple daily injections (MDIs). The primary outcome is to assess the change in HbA1c 6 months after initiating Control-IQ technology.
Methods:
This prospective observational study evaluated children aged 2-14 years with insulin-dependent diabetes who transitioned from treatment with MDI to the Control-IQ technology in the diabetes clinic at the King Faisal Specialist Hospital and Research Centre (KFSHRC) in Saudi Arabia.
Results:
A total of 100 patients (44 boys and 56 girls; median age was 11 years) were included. Most (82%) had a history of severe hypoglycemia. Following Control-IQ initiation, median HbA1c significantly decreased from 9.2% to 6.9% at 6 months (-25.0%; p < 0.001), accompanied by a 24.4% reduction in the daily insulin dose. Time in range (TIR) (70-180 mg/dL) improved from 45.6% to 68.8% (+23.2%; p < 0.001), while time in significant hypoglycemia (<54 mg/dL) decreased by 88.9% (p < 0.001). At 6 months, 83% achieved ≥60% TIR, and 54% reached ≥70%. Adherence and engagement were high, with no severe hypoglycemia or discontinuations. Only 3% experienced mild/moderate ketoacidosis due to technical issues in the Control-IQ.
Conclusions:
The findings demonstrated that Control-IQ technology is both effective and safe in improving glycemic outcomes in children with insulin-dependent diabetes in a real-world clinical setting. However, successful implementation requires comprehensive training and continuous support.
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