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Updated: Mar 6, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Dual-Activated Hydrocarboxylation of Acrylamides with Formate Salts via Radical-Radical Cross-Coupling
Xin-Yue Wang1, You-An Hao1, Yu-Hang Li1
1School of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, P.R. China.
Abstract:
A novel dual-activation strategy for alkene hydrocarboxylation via radical-radical cross-coupling has been developed. This approach synchronously generates an alkenyl radical and CO2•-, favoring direct intermolecular coupling over cyclization. The Lewis acidic iron center could promote the formation of an EDA complex and catalyze enol tautomerization to a persistent allylic radical. This mild protocol provides a green route to succinamic acids and sulfamoyl propanoic acids and a new paradigm for controllable photochemical C-C bond formation.
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