Related Experiment Video
Updated: Mar 6, 2026
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
[Tumor flare reaction during epcoritamab treatment in refractory diffuse large B-cell lymphoma]
Yuki Fujiwara1, Hitomi Tsuchida1,2, Akihiro Kawatsuki1
1Department of Hematology and Oncology, Japanese Red Cross Society Himeji Hospital.
None:
An 87-year-old man was diagnosed with diffuse large B-cell lymphoma in 2020. The disease relapsed repeatedly and remained poorly controlled despite multiple salvage chemotherapy regimens. In February 2024, inguinal lymphadenopathy reappeared and epcoritamab was administered as the sixth line of chemotherapy. Tumor area assessment showed transient increases on days 4, 12, and 17. Macroscopic redness and elevation were also observed. This was considered a tumor flare reaction because it disappeared transiently. We report this case as an example of successful serial imaging of lesions from the start of epcoritamab therapy to visually confirm changes that may constitute a tumor flare reaction.
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