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Updated: Mar 6, 2026
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
A Case of Acute Promyelocytic Leukemia with t(11;17)(q23.2;q21.2) Treated with Haploidentical Transplantation Using
Yujiro Ito1, Ayato Sumioka1, Ibuki Takatsuka1
1Department of Hematology, Hamamatsu Medical Center, Japan.
Abstract:
The majority of acute promyelocytic leukemia (APL) cases have t(15;17)(q24.1;q21.2), but there are rare cases with other chromosomal translocations. These atypical APLs have different morphologies and prognoses than typical APL. We herein report the case of a 55-year-old man with APL and t(11;17)(q23.2;q21.2). The patient was diagnosed with APL based on its distinctive morphology. Later, t(11;17)(q23.2;q21.2) was detected, thus suggesting the presence of the ZBTB16::RARA fusion gene. He underwent haploidentical transplantation using post-transplant cyclophosphamide (PTCy) after conventional chemotherapy and maintained long-term remission. This case highlights the importance of a morphological diagnosis and allogeneic hematopoietic stem cell transplantation (allo-HSCT) in APL with t(11;17)(q23.2;q21.2).
