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The application of process mining for clinical pathways: a systematic literature review protocol
Luca Murazzano1,2,3,4, Paolo Landa5,6,7,8, Frédéric Bergeron9
1Département d'Opérations et Systèmes de Décision, Faculté des Sciences de l'Administration, Université Laval, Québec, G1V 0A6, Canada.
Systematic Reviews
|March 4, 2026
Summary
This systematic review synthesizes evidence on process mining applications in clinical pathways. It highlights how process mining can improve patient outcomes and operational efficiency in healthcare settings.
Area of Science:
- Healthcare Management
- Data Science in Medicine
- Clinical Pathway Optimization
Background:
- Process mining is gaining traction in healthcare for clinical pathway analysis and optimization.
- Applications aim to improve care efficiency and patient outcomes.
- This review focuses on process mining's impact on patient outcomes, operational efficiency, and pathway structure.
Purpose of the Study:
- To systematically review and synthesize existing evidence on process mining applications in clinical pathways.
- To evaluate the impact of process mining on patient outcomes, operational efficiency, and pathway structure.
- To identify successful strategies, challenges, and future opportunities for process mining in healthcare.
Main Methods:
- Systematic literature search across multiple databases (MEDLINE, Embase, Google Scholar, Web of Science, ABI/Inform) from 1999 onwards.
- Inclusion of observational studies, case reports, conference papers, and meta-analyses in hospital settings.
- Data extraction and quality assessment using the Mixed Methods Appraisal Tool (MMAT) by two independent reviewers, followed by narrative synthesis and thematic analysis.
Main Results:
- The review will synthesize findings on process mining's effectiveness in improving care efficiency, patient flow, guideline compliance, and reducing delays/resource use.
- It will identify key challenges and limitations associated with applying process mining techniques in clinical settings.
- Results will be presented thematically to highlight successful strategies and areas for improvement.
Conclusions:
- This review offers a comprehensive overview of process mining in clinical pathways, identifying best practices and potential pitfalls.
- Findings will guide healthcare professionals, policymakers, and researchers in optimizing clinical care through process mining.
- The study aims to inform the strategic implementation of process mining for enhanced healthcare delivery.
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