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Updated: Mar 6, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Regioselective iridium(III)-catalyzed C-H cyclization using an acetylene surrogate: direct access to hydroxylated
Chao Zhang1, Hui Zhang1, Lin Dong1
1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. dongl@scu.edu.cn.
None:
An iridium(III)-catalyzed C-H cyclization between N-arylphthalazinones and 2-chloroacetaldehyde has been developed. This reaction provides efficient access to tetracyclic phthalazine derivatives with broad substrate scope. With the acetylene surrogate's dual electrophilic sites being selectively activated, a series of hydroxylated tetracyclic phthalazine intermediates was also prepared. Notably, the process displays excellent regioselectivity, placing substituents exclusively at the meta-position relative to the nitrogen directing group in the products.
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