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Maintenance and Reliever Therapy in Pediatric Asthma: A Concise Review of Recent Evidence-Part II

Rahaf Alharbi1, Adel S Alharbi2

  • 1Pharmaceutical Services Department, and Department of Pediatrics, Pediatric Sleep Disorders Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Pediatric Annals
|March 5, 2026
PubMed

Insights

Maintenance and Reliever Therapy (MART) simplifies pediatric asthma treatment using a single inhaler for both daily control and symptom relief. This approach shows promise in reducing exacerbations and improving adherence in children with asthma.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Pharmacotherapy

Background:

  • Pediatric asthma is a common chronic respiratory illness.
  • Inhaled corticosteroids (ICS) and long-acting beta-2 agonists (LABAs) are standard treatments.
  • Adherence issues with separate inhalers led to the development of Maintenance and Reliever Therapy (MART).

Purpose of the Study:

  • To review the rationale and clinical efficacy of MART in pediatric asthma.
  • To discuss special considerations and safety concerns associated with MART in children.
  • To highlight the need for further research on MART's long-term effects.

Main Methods:

  • Literature review of recent studies on MART in pediatric asthma.
  • Analysis of clinical trial data comparing MART with traditional ICS-LABA therapy.
  • Examination of safety data, including overuse and effects on growth.

Main Results:

  • MART simplifies treatment regimens by using a single inhaler for maintenance and symptom relief.
  • Studies indicate MART reduces asthma exacerbations and improves adherence compared to traditional therapy.
  • Potential concerns include long-term safety, overuse, and impact on growth and development.

Conclusions:

  • MART offers a simplified and potentially more effective treatment strategy for pediatric asthma.
  • Further research is essential to fully understand the long-term safety and optimal use of MART in children.
  • Individualized treatment strategies are crucial for managing pediatric asthma effectively.

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