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Accelerometer-Derived Physical Activity Associated With Incidence and Progression Trajectory of Cardiometabolic
Fa Shen1, Hao-Yu Liu1, Yu-Yang Liu2
1Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Mayo Clinic Proceedings
|March 5, 2026
Summary
Regular moderate-intensity physical activity (MPA) significantly lowers the risk of developing first cardiometabolic disease (FCMD) and cardiometabolic multimorbidity (CMM). Improving physical activity is a key strategy for preventing CMM.
Area of Science:
- Cardiovascular Health
- Metabolic Disease Prevention
- Public Health
Background:
- Cardiometabolic diseases (CMDs) represent a significant global health burden.
- The progression from single CMD to cardiometabolic multimorbidity (CMM) and subsequent mortality requires further investigation.
- Understanding the role of physical activity (PA) in these disease trajectories is crucial for public health interventions.
Purpose of the Study:
- To investigate the association between objectively measured physical activity (PA) and the transitions from a healthy state to first cardiometabolic disease (FCMD).
- To examine the impact of PA on the progression from FCMD to cardiometabolic multimorbidity (CMM).
- To assess the influence of PA on mortality in individuals with or at risk of CMDs.
Main Methods:
- Utilized accelerometer data from 59,161 participants to objectively measure PA over 7 days.
- Defined CMM as the presence of at least two CMDs (type 2 diabetes, ischemic heart disease, stroke).
- Employed multistate models to analyze the impact of PA on CMD incidence and progression.
Main Results:
- Guideline-adherent moderate-intensity physical activity (MPA; 150-300 min/wk) was associated with a 29% lower risk of FCMD and a 40% lower risk of CMM.
- The protective effect of MPA was stronger in preventing FCMD from a healthy state compared to preventing CMM progression from FCMD.
- Comparable trends of MPA were observed across transitions from healthy baseline to FCMD and subsequent CMM for specific cardiometabolic diseases.
Conclusions:
- Physical activity demonstrates significant and comparable roles in preventing the onset of FCMD and the subsequent development of CMM.
- These findings underscore the potential of enhancing PA as a primary strategy for the prevention of cardiometabolic multimorbidity.
- Promoting MPA is a viable public health approach to mitigate the risk and progression of cardiometabolic diseases.
