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Post-Stroke Motor Fatigability: Defining and Studying the Impairments That Emerge During Prolonged Motor Tasks
Adarsh Mavathaveedu1, Jennifer Paige Hepple1, David A Cunningham2,3,4
1Department of Neurology, University of Rochester School of Medicine, Rochester, NY, USA.
Neurorehabilitation and Neural Repair
|March 5, 2026
Summary
Post-stroke motor fatigability (PSMF) presents challenges in daily activities and rehabilitation. Standardized methods are needed to understand its central and peripheral causes for better patient recovery.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Motor Control
Background:
- Fatigue is common after stroke, significantly impacting motor recovery and daily functioning.
- Post-stroke motor fatigability (PSMF) specifically refers to objective declines in continuous motor performance.
- PSMF can impede rehabilitation progress and limit independence in activities of daily living.
Purpose of the Study:
- To review the current knowledge on post-stroke motor fatigability.
- To evaluate the methodologies used to study the mechanisms underlying PSMF.
Main Methods:
- Review of existing literature on post-stroke motor fatigability.
- Analysis of neurophysiological, neurostimulation, and functional assessment approaches.
- Identification of inconsistencies in terminology and methodology across studies.
Main Results:
- Significant heterogeneity exists in research approaches to PSMF.
- Inconsistent terminology and lack of standardized methods hinder conclusive findings.
- Evidence suggests central neuromuscular factors are more limiting than peripheral ones, but further research is required.
Conclusions:
- Standardized terminology, consistent experimental paradigms, and neurophysiological tools are recommended for future PSMF research.
- Improved research methodologies will facilitate better identification of stroke-specific motor limitations.
- Tailored interventions can be developed to address PSMF and improve patients' ability to manage daily demands.
