Related Experiment Video
Updated: Mar 7, 2026

Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research
Published on: April 18, 2013
Potentiometric Multisensor for Simultaneous Analysis of Relevant Ions in Body Fluids
Barbara Niemiec1, Nikola Lenar1, Beata Paczosa-Bator1
1Faculty of Materials Science and Ceramics, AGH University of Krakow, Krakow, Poland.
Abstract:
A novel potentiometric multisensor system was developed for the simultaneous determination of chloride, potassium, sodium, and calcium ions in human body fluids. The device consists of an integrated platform comprising four ion-selective paste electrodes with renewable sensing surfaces, enabling repeated use and stable performance. Conditioning, calibration, and analysis were performed in mixed solutions containing all target ions, allowing simultaneous determination of calibration curves and significantly reducing analysis time. The multisensor exhibited near-Nernstian slopes, wide linear concentration ranges, high capacitance, and low potential drift, ensuring reliable operation within the physiological pH range. The system was successfully applied to diluted samples of artificial saliva, sweat, and blood serum of biological origin, yielding recovery values between 97% and 108%, thus confirming its accuracy and practical applicability. This work presents an efficient potentiometric platform for simultaneous electrolyte monitoring in complex biological matrices.
More Related Videos
Related Concept Videos
Potentiometry: Membrane Electrodes
High-Performance Liquid Chromatography: Types of Detectors
Mass Analyzers: Common Types
Potentiometry: Overview
Ion-Exchange Chromatography
Mass Spectrometry: Complex Analysis
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...

