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Takotsubo Syndrome Following Inhalation of K4: A Case Report.
Leandro M Valente1, Gabrielle Santos1, Ricardo Velho1
1Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT.
Cureus
|March 6, 2026
Summary
Synthetic cannabinoids like K4 can trigger Takotsubo syndrome (stress cardiomyopathy), a condition mimicking heart attacks. This case highlights K4 use as a potential cause of transient left ventricular dysfunction.
Area of Science:
- Cardiology
- Toxicology
- Pharmacology
Background:
- Takotsubo syndrome (TS), or stress cardiomyopathy, involves temporary left ventricular dysfunction without coronary artery disease.
- It's often triggered by stress, leading to catecholamine release, myocardial stunning, and altered contractility.
- TS can present symptoms similar to acute coronary syndromes.
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