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The role of IL-11 in chronic diseases
Jingxuan Zhang1, Yan Leng1, Wenyuan Li1
1Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Background:
Initially recognized for its role in hematopoiesis, Interleukin-11 (IL-11) is now understood to possess a wide spectrum of biological activities. It is involved in critical physiological processes, including immune cell differentiation, inflammatory response regulation, and tissue repair. Consequently, IL-11 is strongly implicated in the pathogenesis and progression of various chronic diseases.
Discussion:
This review examines the multifaceted biology of IL-11, detailing its discovery, molecular structure, and signaling mechanisms. We also explore its expression patterns across different tissues. A primary focus is placed on elucidating the critical role of IL-11 in the pathogenesis and progression of various chronic diseases. Furthermore, we discuss the emerging therapeutic potential of targeting the IL-11 pathway, evaluating evidence from both experimental models and clinical studies.
Conclusion:
By synthesizing current knowledge on the biological characteristics and disease associations of IL-11, this review aims to provide a comprehensive theoretical foundation for future research into its role in chronic diseases and its potential as a therapeutic target.
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