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Casein Phosphopeptide and Diode Laser in Treating Dentin Hypersensitivity: A Clinical Study
Sanam Faheem1, Rimsha Qasim1, Chander Kumar2
1Department of Oral Biology, Dow Dental College, Dow University of Health Sciences, Karachi, Pakistan.
Journal of Lasers in Medical Sciences
|March 6, 2026
Summary
Diode laser therapy effectively manages dentin hypersensitivity, offering rapid pain relief. Combining Casein phosphopeptide amorphous calcium phosphate (CPP-ACP) with a diode laser is also a viable treatment option for dental hypersensitivity.
Area of Science:
- Dentistry
- Periodontology
- Biomaterials
Background:
- Dentin hypersensitivity causes intense, short-duration pain, posing a treatment challenge for dentists.
- Effective management of dentin hypersensitivity is crucial for patient comfort and oral health.
- Novel therapeutic approaches are continuously explored to address this common clinical issue.
Purpose of the Study:
- To evaluate the efficacy of Casein phosphopeptide amorphous calcium phosphate paste (CPP-ACP) in treating dentin hypersensitivity.
- To compare the effectiveness of CPP-ACP alone versus its combination with diode laser therapy.
- To determine the optimal treatment strategy for managing dental hypersensitivity.
Main Methods:
- A randomized, double-masked clinical trial involving 120 patients with dentin hypersensitivity.
- Patients were assigned to four groups: CPP-ACP paste, diode laser only, CPP-ACP with diode laser, or placebo.
- Pain, discomfort, and tolerance were assessed using the Visual Analog Scale (VAS); data analyzed with two-way ANOVA.
Main Results:
- All treatment groups demonstrated significant reductions in VAS pain, botheration, and tolerance scores.
- The diode laser-only group exhibited the most immediate and substantial improvements in VAS scores post-treatment.
- Both diode laser monotherapy and the combination therapy showed promising results in managing hypersensitivity.
Conclusions:
- Diode laser therapy is highly effective for managing dentin hypersensitivity.
- Combining CPP-ACP with diode laser therapy presents a viable alternative for treating dental hypersensitivity.
- Treatment choice may depend on individual patient needs and preferences for managing dental hypersensitivity.
Keywords:
Casein phosphopeptide pasteDentin hypersensitivityDiode laserFluorideLaser therapyNon-cervical carious lesionToothpaste
