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Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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Assessing Agrochemical Risk to Mated Honey Bee Queens
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A harmonized ecotoxicity dataset for honeybee based on the ECOTOX database.

Junxuan Shi1, Peter Fantke1,2,3,4, Olivier Jolliet1

  • 1Quantitative Sustainability Assessment, Department of Environmental and Resource Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.

Environmental Toxicology and Chemistry
|March 6, 2026
PubMed
Summary

Honeybee colony losses are a major concern. This study created a harmonized pesticide ecotoxicity dataset for honeybees (Apis mellifera), improving environmental impact assessments for crucial pollinators.

Keywords:
ECOTOX databasedata harmonizationecotoxicityhoneybeepesticides

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Area of Science:

  • Ecotoxicology
  • Environmental Science
  • Apiculture

Background:

  • Managed honeybee (Apis mellifera) colonies face significant losses, impacting pollination services and beekeeping economics.
  • Pesticide exposure is a known stressor contributing to these losses, but a comprehensive dataset on its effects is lacking.
  • Existing data lacks harmonization across different honeybee life stages and exposure routes.

Purpose of the Study:

  • To address the data gap by generating a harmonized honeybee ecotoxicity dataset.
  • To standardize pesticide impact data for Life Cycle Impact Assessment (LCIA) and comparative analyses.
  • To provide a reliable resource for assessing pesticide risks to honeybees.

Main Methods:

  • Compiled and harmonized ecotoxicity data (Top-Acute 10% effective dose (ED10) and Oral-Chronic ED10) from the USEPA ECOTOX database.
  • Standardized data on life stages, exposure types, effect types, units, endpoints, and test types.
  • Applied weighted linear regressions to extrapolate endpoints to a harmonized ED10-equivalent (ED10eq).

Main Results:

  • Created an integrated dataset of 540 chemicals across Oral-Chronic, Oral-Acute, and Acute-Topical exposure scenarios.
  • Data spans 8 orders of magnitude for adult honeybees and 6 orders of magnitude for larval honeybees.
  • Analyzed adult-larva ecotoxicity relationships and performed uncertainty assessments for key datasets.

Conclusions:

  • The harmonized dataset significantly enhances the LCIA framework for pesticide impact assessment.
  • Replaced median effective dose (ED50) acute data with more environmentally relevant Oral-Chronic and Top-Acute ED10 data.
  • Facilitates more realistic environmental risk assessments for pesticide impacts on honeybees.