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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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INCIDENCE AND PREVALENCE OF NONINFECTIOUS UVEITIS: A Systematic Review and Meta-Analysis
Aswen Sriranganathan1, Jacob Stasso1, Rafael N Miranda2
1Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Retina (Philadelphia, Pa.)
|March 6, 2026
Summary
Non-infectious uveitis (NIU) is more common in adults than children. Its incidence and prevalence are elevated in patients with conditions such as Juvenile idiopathic arthritis (JIA) and Ankylosing spondylitis (AS).
Area of Science:
- Ophthalmology
- Rheumatology
- Epidemiology
Background:
- Non-infectious uveitis (NIU) represents a significant cause of visual impairment.
- Understanding the epidemiological burden of NIU is crucial for public health planning and resource allocation.
Purpose of the Study:
- To systematically estimate the global incidence and prevalence of non-infectious uveitis (NIU).
- To analyze NIU rates across different age groups and in patients with specific comorbid conditions.
Main Methods:
- A comprehensive systematic literature search was performed across major electronic databases (Ovid Medline, Embase, Scopus) covering publications from 2020 to September 2025.
- Data on NIU incidence and prevalence were extracted and pooled using a random-effects meta-analysis, considering various demographic and comorbidity contexts.
Main Results:
- The meta-analysis included 106 studies out of 15,172 initial records.
- Pooled prevalence of NIU was 131.6 per 100,000 for adults and 27.4 per 100,000 for pediatrics.
- Pooled incidence was 204.4 per 100,000 person-years for adults and 16.0 per 100,000 person-years for pediatrics.
- Significantly higher NIU incidence and prevalence were observed in individuals with Juvenile idiopathic arthritis (JIA), undifferentiated Spondyloarthritis (SpA), Psoriatic arthritis (PsA), Ankylosing spondylitis (AS), and Behcet disease (BD).
- For JIA, prevalence was 129.2 per 1,000 and incidence was 22.4 per 1,000 person-years.
- For SpA, prevalence was 153.5 per 1,000 and incidence was 33.5 per 1,000 person-years.
- For PsA, prevalence was 27.3 per 1,000 and incidence was 13.1 per 1,000 person-years.
- Prevalence for AS and BD was 183.5 per 1,000 and 148.6 per 1,000, respectively.
Conclusions:
- Non-infectious uveitis demonstrates a higher incidence and prevalence in adult populations compared to pediatric populations.
- Specific autoimmune and inflammatory conditions, notably JIA and AS, are associated with increased rates of NIU.
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