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Published on: January 23, 2026
Lung-protective mechanical ventilation is not sex neutral
Davide Chiumello1, Aartik Sarma2
1Department of Health Sciences, University of Milan, Milan, Italy; Coordinated Research Center on Respiratory Failure, University of Milan, Milan, Italy; Department of Anesthesia and Intensive Care, ASST Santi Paolo e Carlo, San Paolo University Hospital, Milan, Italy.
Lung-protective ventilation using low tidal volumes helps prevent ventilator-induced lung injury. However, females with acute respiratory distress syndrome (ARDS) may receive it less often and benefit less due to physiological and biological differences.
Area of Science:
- Critical Care Medicine
- Pulmonology
- Mechanical Ventilation
Background:
- Ventilator-induced lung injury (VILI) is a significant concern in critical care.
- Lung-protective ventilation (LPV) with low tidal volumes is a key strategy to mitigate VILI.
- Acute respiratory distress syndrome (ARDS) exhibits higher mortality in females than males.
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