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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Two models, one question: how does respiratory syncytial virus cause asthma?
Tina Hartert1, Ray Stokes Peebles2
1Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Abstract:
De Leeuw et al. conducted human observational and murine studies to establish the combined role of parental aeroallergen sensitization and early-life respiratory syncytial virus infection in asthma development. The findings reveal synergistic effects driving immunological, pathological, and physiological changes resembling asthma, advancing the understanding of disease mechanisms and potential preventive targets.
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