Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.9K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

3.7K
The pathophysiology of pneumonia involves the following steps:
3.7K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.6K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The <u>W</u>heezing, <u>A</u>sthma and <u>V</u>iral effects on the <u>E</u>pithelial <u>S</u>tructure and function (WAVES) birth cohort study: rationale, design and methods to understand airway development and the role of early-life respiratory viral infections on childhood asthma inception.

BMJ open respiratory research·2026
Same author

Stability and age-specific patterns of rhinovirus circulation in children observed over 3 decades.

The Journal of allergy and clinical immunology·2026
Same author

Breathing new life: Rethinking how we measure and promote respiratory health.

The Journal of allergy and clinical immunology·2026
Same author

Redlining, Community Wealth, and Air Pollution: A Tale of Three Cities-Boston, Nashville, and Detroit.

Journal of urban health : bulletin of the New York Academy of Medicine·2026
Same author

Air Pollution Exposure and Birth Weight in the ECHO Cohort.

JAMA network open·2026
Same author

Residential mobility during pregnancy and birth outcomes in the United States: The environmental influences on Child Health Outcomes (ECHO) Cohort (2010-2019).

Annals of epidemiology·2026

Related Experiment Video

Updated: Mar 8, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.4K

Two models, one question: how does respiratory syncytial virus cause asthma?

Tina Hartert1, Ray Stokes Peebles2

  • 1Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

Trends in Immunology
|March 6, 2026
PubMed
Summary

Parental exposure to allergens and early respiratory syncytial virus infection synergistically increase asthma risk. These combined factors drive key changes, offering new targets for asthma prevention strategies.

More Related Videos

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

17.4K
An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
09:14

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

11.6K

Related Experiment Videos

Last Updated: Mar 8, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.4K
Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

17.4K
An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
09:14

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

11.6K

Area of Science:

  • Immunology
  • Pulmonology
  • Allergy Research

Background:

  • Asthma development is multifactorial.
  • Early-life infections and allergen exposure are implicated.
  • Understanding combined risk factors is crucial for prevention.

Purpose of the Study:

  • To investigate the combined role of parental aeroallergen sensitization and early-life respiratory syncytial virus (RSV) infection in asthma development.
  • To elucidate the synergistic effects of these factors on asthma pathogenesis.

Main Methods:

  • Human observational studies.
  • Murine models of asthma.
  • Immunological, pathological, and physiological assessments.

Main Results:

  • Parental aeroallergen sensitization and early-life RSV infection exhibit synergistic effects on asthma development.
  • Combined exposure leads to significant immunological, pathological, and physiological changes characteristic of asthma.
  • Specific mechanisms driving these changes were identified.

Conclusions:

  • The interplay between parental aeroallergen sensitization and early-life RSV infection is a critical driver of asthma.
  • These findings highlight potential preventive strategies targeting these combined risk factors.
  • Further research into these synergistic mechanisms can inform novel therapeutic approaches for asthma.