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Whole-Body MRI Screening of Average Risk Populations: Promises and Controversies.

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Area of Science:

  • Radiology and Medical Imaging
  • Preventive Medicine
  • Health Technology Assessment

Background:

  • Whole-body magnetic resonance imaging (WB-MRI) is increasingly used for multi-organ assessment.
  • Its application has expanded from high-risk surveillance to screening average-risk individuals.
  • Controversies exist regarding the benefits and harms of WB-MRI for general population screening.

Purpose of the Study:

  • To review the potential strengths and drawbacks of WB-MRI as a screening tool for average-risk individuals.
  • To highlight the divergence from conventional screening principles in multi-disease screening.
  • To inform future research and implementation strategies for screening WB-MRI.

Main Methods:

  • Narrative review of existing literature on WB-MRI.
  • Analysis of proposed benefits and controversies in consumer screening.
  • Evaluation of evidence regarding diagnostic performance and clinical utility.

Main Results:

  • WB-MRI may offer convenience by assessing multiple conditions simultaneously.
  • Screening asymptomatic, average-risk groups diverges from standard screening protocols.
  • Evidence on testing efficiency, clinical utility, and cost-effectiveness for large-scale screening is limited.

Conclusions:

  • The clinical utility and cost-effectiveness of screening WB-MRI for average-risk individuals are not yet established.
  • Rigorous assessment of potential benefits and harms is crucial.
  • Addressing current evidence gaps will guide the evolution of screening WB-MRI.