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Targeting amino acid metabolic pathways: a novel therapeutic strategy for hyperuricemia-associated complications

Xinya Zhang1,2, Wenkai Wang1, Le Yang1

  • 1State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Dade Road 111, Guangzhou, China.

Amino Acids
|March 7, 2026
PubMed

Insights

Hyperuricemia causes gout, kidney, and heart issues. Targeting amino acid metabolism offers a new way to treat these complications by addressing underlying metabolic problems.

Area of Science:

  • Biochemistry
  • Metabolic Disorders
  • Nephrology

Background:

  • Hyperuricemia (HUA) is a metabolic disorder linked to gout arthritis (GA), chronic kidney disease (CKD), and cardiovascular disease (CVD).
  • Current treatments for HUA lower serum uric acid but do not resolve the metabolic dysregulation causing tissue damage.
  • Disrupted amino acid (AA) metabolism in key tissues is increasingly recognized as central to HUA-related complications.

Purpose of the Study:

  • To review recent findings on amino acid metabolic pathways implicated in HUA complications.
  • To explore the therapeutic potential of targeting tissue-specific amino acid metabolism for HUA management.

Main Methods:

  • Literature review of current research on amino acid metabolism and hyperuricemia.
  • Synthesis of evidence linking specific amino acid pathways to HUA pathogenesis and complications.

Main Results:

  • Dysregulated amino acid metabolism in bone, kidney, and vascular tissues is a key factor in HUA progression and associated diseases.
  • Specific amino acid metabolic pathways present viable therapeutic targets for mitigating HUA-related tissue damage.

Conclusions:

  • Targeting tissue-specific amino acid metabolism represents a novel therapeutic strategy for hyperuricemia.
  • Precision modulation of amino acid metabolism holds promise for preventing and treating HUA-associated conditions like gout, CKD, and CVD.

Keywords:
Amino acid metabolismHyperuricemiaMetabolic complicationsMetabolic regulationTherapeutic targeting

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