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Polyhydroxylated steroids from the Vietnamese starfish Luidia maculata
Tran Thi Hong Hanh1, Le Thi Vien1, Ninh Thi Ngoc1
1Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Viet Nam.
Abstract:
Applying various chromatographic separations, six polyhydroxylated steroids including four new ones, maculasteroids A-D (1-4), were isolated from the Vietnamese starfish Luidia maculata. Their structures were elucidated by detailed analysis of 1D, 2D NMR and HR QTOF mass spectra. The 3β,5,6β,7α,15α,16β-hexol 15-sulfate (1 and 2) and 2β,3β,5,6β,7α,15α,16β-heptol 15-sulfate (3) steroid cores were reported for the first time in polyhydroxylated steroids to date. In addition, the best antiproliferative activity among the isolated compounds was recorded for 5α-cholestane-3β,5,6β,7α,15α,16β,26-heptol (5) on all five cell lines SK-LU-1 (lung carcinoma), HepG2 (hepatocarcinoma), MCF7 (breast carcinoma), LNCaP (prostate carcinoma), and KB (carcinoma in the mouth) and 5α-cholestane-3β,6β,7α,15α,16β,26-hexol (6) on LNCaP and KB cell lines with IC50 values ranging from 10.40 ± 0.38 to 19.91 ± 1.22 µM.
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