Laboratory Reference Patterns and Survival after Fenestrated Endovascular Aortic Repair: A Retrospective
Emanuel Greistofer1, Fadi Taher1, Afshin Assadian1
1Department of Vascular and Endovascular Surgery, Klinik Ottakring, Vienna, Austria.
Annals of Vascular Surgery
|March 9, 2026
Summary
Postoperative elevated leukocyte and creatinine levels after fenestrated endovascular aortic repair (FEVAR) may predict mortality. However, most lab changes are not independently prognostic for FEVAR outcomes.
Area of Science:
- Vascular Surgery
- Surgical Outcomes
- Prognostic Biomarkers
Background:
- Fenestrated endovascular aortic repair (FEVAR) is a complex procedure.
- Identifying prognostic markers for FEVAR outcomes is crucial for patient management.
Purpose of the Study:
- To assess the prognostic significance of routine postoperative laboratory parameters in FEVAR patients.
- Evaluate renal function, inflammatory markers, and hematologic indices.
Main Methods:
- Retrospective single-center study of 210 FEVAR patients.
- Analysis of perioperative laboratory changes using maximum value metrics.
- Cox proportional hazards models and landmark analyses were employed.
Main Results:
- Elevated maximum leukocyte count and serum creatinine were linked to short- and long-term mortality.
- Hemoglobin, C-reactive protein, and platelet counts were not associated with survival.
- Leukocyte elevation predicted midterm mortality, while creatinine's significance waned after one year.
Conclusions:
- Most postoperative laboratory abnormalities after FEVAR are physiological responses, not independent prognostic indicators.
- Only elevated maximum leukocyte and creatinine values showed a modest association with increased mortality.
- Complex time-dependent modeling did not offer additional prognostic value.
