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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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The Novel HLA-DPB1*1759:01 Allele Was Identified by Next-Generation Sequencing.

Min-Kyung So1, Seunghwan Kim1, Sori Lim2

  • 1Department of Laboratory Medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea.

HLA
|March 9, 2026
PubMed
Summary

This study identifies a novel Human Leukocyte Antigen (HLA) DPB1 variant, HLA-DPB1*1759:01. This new allele differs from HLA-DPB1*02:01:02:01 by a single nucleotide change in exon 4.

Keywords:
HLA‐DPB1*1759:01next‐generation sequencingnovel allele

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Area of Science:

  • Immunogenetics
  • Molecular biology
  • Human leukocyte antigen (HLA) system

Background:

  • The Human Leukocyte Antigen (HLA) system plays a critical role in immune response and transplantation.
  • Accurate HLA typing is essential for matching donors and recipients and understanding immune-related diseases.

Purpose of the Study:

  • To report and characterize a newly identified HLA-DPB1 allele, designated HLA-DPB1*1759:01.
  • To provide detailed molecular information regarding the differences between this novel allele and known alleles.

Main Methods:

  • Sequence analysis of the HLA-DPB1 gene.
  • Comparison of nucleotide sequences to identify variations.
  • Nomenclature assignment based on established HLA sequencing rules.

Main Results:

  • A novel HLA-DPB1 allele, HLA-DPB1*1759:01, has been identified.
  • This allele differs from the known allele HLA-DPB1*02:01:02:01 at codon 221 in exon 4, with a nucleotide substitution from AGC to ATT.

Conclusions:

  • The discovery of HLA-DPB1*1759:01 expands the known HLA-DPB1 allele repertoire.
  • This finding contributes to the ongoing efforts in high-resolution HLA typing and immunogenetic research.