Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Remote blunt chest trauma as a cause of right ventricular deformity: multimodality evaluation.

Journal of echocardiography·2026

Same author

Spatial Proximity Between PD-L1(+) Tumor-Associated Macrophages and CD8(+) T Cells Influences Response to Atezolizumab Plus Bevacizumab in Hepatocellular Carcinoma.

Cancers·2026

Same author

Developing a core outcome set for the NeuroPoint Alliance Quality Outcomes Database Pediatric Tumor Surgery Registry: a modified Delphi study.

Journal of neuro-oncology·2026

Same author

An examination of sexual dysfunction in a cohort of women cancer survivors.

Cancer survivorship research & care·2026

Same author

Complete response to Nivolumab-based chemotherapy in a case of advanced gastric cancer with multiple immune-related adverse events.

Clinical journal of gastroenterology·2026

Same author

Recurrent Cytopathic Effects and Prolonged Viral Shedding in an Immunocompromised Patient With Malignant Lymphoma Treated With Rituximab and Bendamustine: A Case of Coronavirus Disease 2019 Relapse.

Clinical case reports·2026

Same journal

Immunohistochemistry (IHC) Versus Genomic Profiling in Cancer: Roles in Precision Medicine.

Cureus·2026

Same journal

Pediatric Nasal Tip Reconstruction After a Donkey Bite Using an Expanded Paramedian Forehead Flap With Conchal Cartilage Grafts: A Case Report.

Cureus·2026

Same journal

Splenic Rupture: A Delayed and Rare Complication of Colonoscopy.

Cureus·2026

Same journal

Super-refractory Status Epilepticus in Febrile Infection-Related Epilepsy Syndrome Triggered by Influenza A: A Pediatric Case Report.

Cureus·2026

Same journal

Comparative Evaluation of Serum Peroxiredoxin 2 (PRDX2), Serum Peroxiredoxin 4 (PRDX4), and Plasma Methylated Septin 9 (mSEPT9) Levels Against Conventional Biomarkers for Early Detection of Colorectal Cancer: A Study Protocol.

Cureus·2026

Same journal

Inspiratory Muscle Training for Patients With Chronic Obstructive Pulmonary Disease: A Narrative Review.

Cureus·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 6, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

Can Transcutaneous Vagus Nerve Stimulation be Effective After Rats' Spinal Cord Injury?

Tomoko Tanaka¹, Murat Gokden², Reid D Landes³

¹Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, USA.

|March 9, 2026

Summary

This summary is machine-generated.

Transcutaneous vagus nerve stimulation (t-VNS) did not significantly alter macrophage distribution after spinal cord injury (SCI). However, trends suggest t-VNS may reduce M1 macrophage activation, indicating a potential anti-inflammatory effect.

Keywords:

macrophage neuroinflammation recovery rodent spinal cord injury transcutaneous electrical nerve stimulation vagus nerve stimulation

More Related Videos

Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations

Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations

Published on: January 7, 2019

Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions

Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions

Published on: January 19, 2024

Related Experiment Videos

Last Updated: May 6, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations

Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations

Published on: January 7, 2019

Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions

Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions

Published on: January 19, 2024

Area of Science:

Neuroscience
Immunology
Regenerative Medicine

Background:

Spinal cord injuries (SCIs) result from trauma and lack curative treatments.
SCIs involve primary mechanical damage and secondary inflammatory responses leading to cell death.
Mitigating neuroinflammation is crucial for treating secondary SCI, with vagus nerve stimulation (VNS) being a potential modality.

Purpose of the Study:

To investigate the effect of transcutaneous VNS (t-VNS) on the inflammatory processes following SCI.
To assess the impact of t-VNS on macrophage populations in a rat SCI contusion model.

Main Methods:

A spinal cord injury (SCI) contusion model was established in male Sprague-Dawley rats.
Histopathological analysis compared macrophage populations (M1, M2a, M2b, M2c) between rats receiving t-VNS and a control group.

Main Results:

No statistically significant differences were observed in M1, M2a, M2b, or M2c macrophage levels between the t-VNS and control groups (p>0.27).
Post-hoc analysis revealed a more rapid decline in M1 macrophages over time in the t-VNS group (Spearman r = -0.50).

Conclusions:

Transcutaneous VNS did not significantly alter overall macrophage distribution post-SCI.
Observed trends of reduced M1 macrophage activation suggest a potential anti-inflammatory effect of t-VNS in the context of SCI.