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Transnasal-Transoral Endoscopic Surgery Followed by Radiotherapy for Nasopharyngeal Spindle Cell Carcinoma
Yuji Kanazawa1, Yoshiharu Kitani1, Aya Matsubara1
1Department of Otolaryngology-Head and Neck Surgery, Shizuoka General Hospital, Shizuoka, JPN.
Cureus
|March 9, 2026
Summary
A minimally invasive endoscopic approach combined with radiotherapy offers effective treatment for rare nasopharyngeal spindle cell carcinoma (SpCC) in elderly patients with comorbidities. This technique achieved disease-free survival for over three years.
Area of Science:
- Otolaryngology
- Head and Neck Surgery
- Oncology
Background:
- Spindle cell carcinoma (SpCC) is a rare, aggressive head and neck malignancy.
- Nasopharyngeal SpCC is exceptionally rare, with unclear optimal management, especially for patients with comorbidities.
- Elderly patients with comorbidities pose challenges for conventional, highly invasive surgical treatments.
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