Underrecognized Thrombotic Risk in Klinefelter Syndrome: A Clinical Insight
Hrithik Dakssesh Putta Nagarajan1, Mohammed Afsharhussain Hithayathulla1, Tejashvi Rameshkumar2
1Department of Internal Medicine, Madurai Medical College, Madurai, IND.
Cureus
|March 9, 2026
Summary
Klinefelter syndrome (KS), a common male aneuploidy, is linked to an underrecognized risk of venous thromboembolism. This case highlights the need for awareness and further research into KS-associated thrombosis mechanisms.
Area of Science:
- Endocrinology
- Genetics
- Hematology
Background:
- Klinefelter syndrome (47,XXY) is the most common male aneuploidy.
- KS is associated with hypogonadism, gynecomastia, infertility, and venous thromboembolism (VTE).
- Mechanisms of VTE in KS patients lacking other thrombophilic conditions are poorly understood.
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