Development of Scaffold Based on Buriti Oil and PEG-400 at Low Temperature

Bone mass loss due to trauma or disease is a growing problem, requiring biocompatible and structurally stable materials for bone regeneration. In this study, interconnected porous scaffolds were developed from monoacylglyceride (MAG) derived from buriti oil (OB), combined with PEG-400, to examine the feasibility of MAG/PEG-400 as a biomedical scaffold to overcome the disadvantages of traditional implants. Fourier transform infrared (FTIR) analyses confirmed the formation of the scaffolds (Sc1 and Sc2), and scanning electron microscopy (SEM) images revealed porous structures with aver-age pore sizes of 248 and 258 μm, ideal for bone regeneration. The presence of β-carotene in the scaffolds was evidenced by UV-vis, and their thermal stability exceeded 200 °C. MTT assays indicated cell viability comparable to the control, while hemolysis tests revealed higher hemolytic activity in Sc1, possibly due to PEG-400. These OB-based polyurethanes stand out as a promising innovation, providing a suitable cellular microenvironment for bone regeneration and representing a significant contribution to sustainable biomaterials in tissue engineering (TE).