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Updated: Apr 30, 2026
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2-Cyano-N'-[(1E)-1-(3,4-di-meth-oxy-phen-yl)ethylidene]acetohydrazide
Meiyazhagan Manvizhi1, Srinivasan Senthilkumar1, Sivashanmugam Selvanayagam2
1Department of Chemistry Annamalai University, Annamalainagar Chidambaram 608 002 India.
Abstract:
The non-H part of the mol-ecule of the title compound, C13H15N3O3, is nearly planar, with the 2-cyano-N'-[(1E)-ethyl-idene]acetohydrazide moiety and the dimeth-oxy phenol ring forming a dihedral angle of 2.5 (1)°. Inter-molecular N-H⋯O, C-H⋯O and C-H⋯π inter-actions are mainly responsible for the cohesion within the crystal structure. The inter-molecular inter-actions were qu-anti-fied and analysed using Hirshfeld surface analysis, revealing that H⋯H inter-actions contribute most to the crystal packing (36.9%). The volume of the crystal voids was calculated to be 167.8 Å3 (13% of the unit-cell volume).
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