1-(4-Bromo-phen-yl)-4,5-diphenyl-2-(1H-pyrrol-2-yl)-1H-imidazole
Seeralan Nagaraj1, Nagarajan Loganathan1,2
1School of Chemistry Bharathidasan University, Tiruchirappalli 620 024 Tamilnadu India.
Iucrdata
|March 9, 2026
Summary
This study details a novel compound, C25H18BrN3, with potential anti-cancer, antibiotic, and antifungal activities. Its crystal structure reveals specific intermolecular interactions that may influence its biological properties.
Area of Science:
- Crystallography
- Medicinal Chemistry
- Materials Science
Background:
- The development of new therapeutic agents is crucial for combating diseases.
- Exploring novel chemical entities with diverse biological activities is a key research area.
- Understanding the structure-activity relationship is essential for drug design.
Purpose of the Study:
- To synthesize and characterize a new compound, C25H18BrN3.
- To investigate the potential anti-cancer, antibiotic, and antifungal properties of the compound.
- To analyze the crystal structure and intermolecular interactions.
Main Methods:
- Single-crystal X-ray diffraction to determine the crystal structure.
- Standard biological assays to evaluate anti-cancer, antibiotic, and antifungal activities.
- Computational analysis of intermolecular interactions.
Main Results:
- The compound C25H18BrN3 was successfully synthesized and its crystal structure determined in the triclinic P1 space group.
- Preliminary investigations suggest potential anti-cancer, antibiotic, and antifungal activities.
- The crystal structure exhibits various intermolecular interactions including N-H⋯N, C-H⋯N, C-H⋯π, N-H⋯π, C-H⋯Br, and C-Br⋯π.
Conclusions:
- The synthesized compound C25H18BrN3 possesses a unique crystal structure with significant intermolecular interactions.
- The identified biological activities warrant further investigation for therapeutic applications.
- Further studies are recommended to elucidate the mechanism of action and optimize the compound's efficacy.
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